嗜酸细胞性胃肠炎的研究现状

嗜酸细胞性胃肠炎是以胃肠道组织中嗜酸性粒细胞异常浸润为特征的胃肠道少见疾病。发病机理尚未明确,自1937年首次报道以来,国内外仅有300余例报道,且报道的病例特点不一,具有临床多样性,容易造成误诊。本文就嗜酸性胃肠炎的诊治进行阐述。     

嗜酸细胞性胃肠炎研究进展

嗜酸细胞性胃肠炎(eosinophilic gastroenteritis,EG)是一种少见的胃肠道疾病,以胃肠道某些部位弥漫性或局限性嗜酸性粒细胞(Eos)浸润为特征。胃和小肠为最常受累部位,可发生于任何年龄,其好发年龄为30～50岁,儿童时期较罕见,男性发病率高于女性。由于许多EG患者被误     

90例苯暴露者T淋巴细胞核仁组成区嗜银蛋白检测

目的检测苯暴露者外周血T淋巴细胞核仁组成区嗜银蛋白（Ag-NORs）,评价其作为苯暴露者早期的效应生物标志物的价值。方法采用KL型肿瘤免疫图像分析系统及配套试剂分析接触苯的高暴露者、低暴露者和对照者Ag-NORs区面积与细胞核仁区的百分比（I.S%）。结果 I.S%在高暴露者组为（6.2±0.7）,低暴露组为（7.5±0.8）,正常对照组为（7.6±0.7）,3组差异有统计学意义（F=2.36,P=0.013）,其中高暴露组低于低暴露组和对照组,低暴露组与对照组比较差异无统计学意义（P〉0.05）。结论 Ag-NORs检测能反映个体的苯接触水平,对职业健康检查早期筛查易感人群有一定的意义。     

浆膜型嗜酸性粒细胞性胃肠炎1例

嗜酸性粒细胞性胃肠炎（eosinophilic gastroenteritis,EG）,是一种以胃肠道某些部位局限性或弥漫性嗜酸性粒细胞浸润为特征的疾病。临床上分为3型：（1）黏膜型：最常见,主要为胃肠道粘膜内大量嗜酸性粒细胞浸润,以消化吸收不良为主要表现;（2）肌层型,较少见,主要表现为胃肠壁增厚,僵硬呈结节状,可引起幽门梗阻及肠梗阻;     

Tracheobronchial lesions in eosinophilic pneumonia

BackgroundEosinophilic pneumonia (EP) is characterized by eosinophil infiltration in the lung parenchyma. However, tracheobronchial lesions associated with the disease have been poorly described. To clarify the frequency and characteristics of cases with tracheobronchial lesions in EP, we performed a retrospective review of EP patients.MethodsWe included 36 EP cases seen from January 2004 to December 2007 at the Kinki-Chuo Chest Medical Center. The incidence of tracheobronchial nodules and associated clinical features were analyzed.ResultsOf these 36 patients, 29 had chronic eosinophilic pneumonia (CEP); 1, acute EP; 3, drug-induced EP; 2, allergic bronchopulmonary aspergillosis; and 1, parasite-related EP. Only 2 of the 29 CEP cases had tracheobronchial lesions. For both of these cases, bronchoscopy revealed multiple whitish nodules on the tracheobronchial mucosa. The associated histopathological findings revealed squamous metaplasia and eosinophil infiltration in the subepithelial region. In both cases, the nodules disappeared after steroid therapy. The prevalence of tracheobronchial lesions was 6.9% in CEP patients and 5.6% in EP patients overall. EP patients were divided into 3 groups: CEP with nodules (n=2), CEP without nodules (n=27), and other EP (n=7). We found that the CEP with nodules group showed a relatively higher incidence of respiratory symptoms, higher white blood cell (WBC) count, and higher levels of peripheral and bronchoalveolar eosinophilia than the other groups.ConclusionsTracheobronchial nodules represent rare observations within the EP population, which are likely to reflect a severe disease condition.